Drug intelligence / Profile preview

astragalin

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Intraperitoneal
01

Overview

Astragalin is a naturally occurring flavonoid compound (kaempferol 3-O-glucoside) that belongs to the class of flavonoid-3-O-glycosides. It appears as a **yellow solid powder** with diverse pharmacological properties including **anti-inflammatory**, **antioxidant**, **neuroprotective**, **cardioprotective**, **anti-obesity**, **antiosteoporotic**, **anticancer**, **antiulcer**, and **antidiabetic** activities. The compound exerts its effects through modulation of various molecular targets including transcription factors (NF-κB, TNF-α, TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3), kinases (JNK, MAPK, Akt, ERK), and inflammatory cytokines. It can be isolated from various edible plants including green tea seeds, Morus alba L., Cuscuta chinensis, American pokeweed (Phytolacca americana), and is also found in wine and various food items such as tamarind, American cranberry, chickpea, and bilberry.

Other names
kaempferol 3-O-glucosidekaempferol3-O-glucosidekaempferol-3-O-glucosidekaempferol-3-glucosidekaempferol3-glucosidekaempferol 3-glucosideastragalinekaempferol 3-O-β-D-glucopyranosidekaempferol 3-β-D-glucopyranosidekaempferol-3-O-beta-D-glucopyranosidekaempferol3-O-beta-D-glucopyranosidekaempferol 3-O-beta-D-glucopyranoside5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
02

Targets

NOS2 (Nitric Oxide Synthase 2)MAPK3 (Mitogen-activated protein kinase 1)RK (Ribokinase)JNK (Mitogen-activated protein kinase kinase kinase family)

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