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Drug intelligence / Profile preview
astragaloside II
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Astragaloside II is a cycloartane-type triterpene glycoside (saponin) isolated from Astragalus membranaceus. It exhibits pharmacological activities such as anti-inflammatory, immunomodulatory, antioxidant, and tissue repair promotion. Astragaloside II modulates mitochondrial dynamics and autophagy in podocyte injury (particularly in diabetic nephropathy), enhances antioxidative stress via Nrf2 pathway activation, induces mitophagy through PINK1-Parkin signaling, and promotes intestinal epithelial repair by increasing L-arginine uptake and activating the mTOR signaling pathway. These mechanisms may provide novel therapeutic strategies for inflammatory, renal, and gastrointestinal diseases[1][3][4].
- Other names
- AS IIastragaloside II
02
Targets
PTPRC (Receptor-type tyrosine-protein phosphatase C)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PINK1 (PTEN-induced kinase 1)AKT (RAC-alpha serine/threonine-protein kinase)SLC7A1 (Cationic amino acid transporter 1)SLC7A2 (Solute carrier family 7 member 2)
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