astragaloside iv

Astragaloside IV is a cycloartane-type triterpene glycoside and the primary bioactive saponin isolated from the roots of Astragalus membranaceus (also known as Huangqi), a widely used herb in traditional Chinese medicine. It exhibits multiple pharmacological effects, including cardioprotective, neuroprotective, hepatoprotective, anti-inflammatory, antioxidant, anti-apoptotic, immunomodulatory, and antitumor activities. Mechanistically, astragaloside IV modulates several cellular signaling pathways such as Raf-MEK-ERK, EGFR-Nrf2, Akt/PDE3B/AMPK/mTOR/NF-κB/Nrf2/PI3K/JNK/c-Jun/AP1/IL11/STAT3/Akt/GSK3β/β-catenin/Nox4/Smad2 and others. Preclinical studies have demonstrated its potential in treating cardiovascular diseases (including heart failure and myocardial infarction), liver diseases (including metabolic-associated fatty liver disease and liver fibrosis), neurological disorders (such as ischemic stroke), diabetes mellitus, cancer prevention/treatment by inducing apoptosis in tumor cells and reversing drug resistance during chemotherapy. While it has shown promise in animal models for these indications due to its low toxicity profile and broad biological activity spectrum[1][5][6][7][8], clinical evidence remains limited.

Other names

AS-IVAstragaloside IV (C41H68O14)cycloastragenol glycoside