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astragalus + atractylodes

Development stage
Unknown
Lead developer
Sun Ten
Administration
Oral
01

Overview

This is a **combination herbal product** used primarily in traditional Chinese medicine (TCM), consisting of **astragalus root (Astragalus membranaceus)**—known for its immunomodulatory, adaptogenic, and anti-inflammatory properties—and **atractylodes root (most commonly Atractylodes macrocephala or Atractylodes lancea)**—noted for its gastrointestinal tonic effects and as a leading qi tonifier[2][3][4][5][7][8]. It is used to enhance immune function, tonify qi (vital energy), strengthen digestion, and address conditions associated with spleen deficiency and dampness. Common mechanisms attributed to this combination include modulating immune responses, balancing gut flora, improving gastrointestinal health, and exhibiting anti-inflammatory activity[3][4]. In TCM, astragalus and atractylodes are frequently included together as key components of classic formulas for deficiency and chronic disorders, such as fatigue, lowered immunity, and gastrointestinal dysfunction[2][3][4][5][6][7][8]. *Pharmacokinetic studies show synergistic enhancement of astragaloside IV absorption when combined with atractylenolide I from atractylodes*[4]. Modern use includes combinations with other TCM herbs for complex formulations targeting chronic disease support and cancer care, but the specific combination "astragalus + atractylodes" is most associated with qi tonic blends and immune support[2][3][5][7][8]. Products are available as powders, granules, tablets, and decoctions.

Brand names
Evergreen Astragalus & Atractylodes CombinationSun Ten Astragalus & Atractylodes Combination
Other names
Qing Shu Yi Qi Tangastragalus and atractylodes combinationRadix Astragali + Rhizoma AtractylodisHuang Qi + Bai Zhu
02

Targets

NF-κBJUN (Transcription factor Jun)MAPK14 (p38 mitogen-activated protein kinase alpha)MYC (MYC proto-oncogene protein)TLR4 (Toll-like receptor 4)TP53 (Cellular Tumor Antigen p53 R175H)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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