Drug intelligence / Profile preview

astragalus membranaceus

Development stage
Phase 4
Lead developer
PhytoHealth
Administration
Oral, Intravenous, Topical
01

Overview

Astragalus membranaceus is a traditional Chinese medicinal herb derived from the root of Astragalus membranaceus and used as a botanical drug or herbal medicine rather than a single defined molecular entity. Its pharmacology is multi-component and pleiotropic, with commonly cited active constituent groups including astragalosides, astragalus polysaccharides, and cycloastragenol; reported mechanisms in preclinical literature include immunomodulatory, antioxidant, anti-inflammatory, endothelial-protective, neuroprotective, and telomerase-activating effects. In the provided public sources, it appears as the exact intervention in registered or protocol-level clinical development for mild-to-moderate Alzheimer's disease with orthostatic hypotension, Alzheimer's disease more broadly, α-synucleinopathy-associated non-motor symptoms, diabetic kidney disease, metabolic syndrome, gastric cancer adjunctive immunotherapy, and beta-thalassemia, among other settings where it is also included as a component of multi-herb formulas. Because this asset is a crude botanical/herbal drug with variable formulations such as decoction pieces or granules, it should be annotated as a plant-derived medicinal product with incompletely standardized composition rather than a conventional single-target pharmaceutical.

Brand names
Huangqi Koufuye
Other names
Huangqihuang qiRadix AstragaliMilkvetch Root
02

Targets

HMGB1 (High mobility group protein B1)TLR4 (Toll-like receptor 4)

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