Drug intelligence / Profile preview

astragalus root extract

Development stage
Unknown
Lead developer
First Affiliated Hospital, Zhejiang University School of Medicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Astragalus root extract is a botanical product derived from the roots of *Astragalus membranaceus* or *Astragalus mongholicus*, plants central to Traditional Chinese Medicine (TCM). The extract contains a complex mixture of bioactive compounds, including polysaccharides (astragalans), triterpene saponins (astragalosides I–VIII), and flavonoids (formononetin, calycosin). It is primarily investigated for its immunomodulatory, anti-inflammatory, and antioxidant properties. In clinical research, such as the study conducted by the First Affiliated Hospital of Zhejiang University, it is evaluated for its potential to modulate drug transporters like P-glycoprotein (P-gp), which could lead to significant herb-drug interactions when co-administered with P-gp substrates like fexofenadine.

Other names
Astragalus membranaceus extractHuang Qi extractastragalus root extract granules
02

Targets

ABCB1 (P-glycoprotein)

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