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astragalus total saponins
- Development stage
- Unknown
- Lead developer
- Shanxi Zhendong Taisheng Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Astragalus total saponins (ATS) is a purified botanical extract derived from the root of *Astragalus membranaceus* (Fisch.) Bunge, a staple of Traditional Chinese Medicine. Developed as a pharmaceutical product by Shanxi Taisheng Pharmaceutical, it is primarily indicated for the treatment of chronic stable angina pectoris. The extract is a complex mixture of triterpene saponins, with Astragaloside IV serving as a key active constituent and quality marker. ATS exerts cardioprotective effects by improving myocardial energy metabolism, reducing oxidative stress, and inhibiting cardiomyocyte apoptosis. It has been shown to activate the PI3K/Akt signaling pathway and modulate calcium homeostasis via the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), thereby enhancing cardiac function and alleviating ischemic symptoms in patients with coronary heart disease.
- Brand names
- Huangqi Zong Zao Gan
- Other names
- ATSAstragalus saponinsTotal saponins of AstragalusHuangqi Zong Saponins
02
Targets
ATP2A (Sarcoplasmic reticulum Ca2+-ATPase)
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