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Astressin C
- Development stage
- Preclinical
- Lead developer
- Sentia Medical Sciences
- Modality
- Peptides
- Administration
- Subcutaneous
01
Overview
Astressin C is a long-acting peptide antagonist of the corticotropin-releasing factor receptors 1 and 2 (CRF1 and CRF2). Developed by Sentia Medical Sciences in collaboration with the Salk Institute, it is designed to treat stress-related gastrointestinal and endocrine disorders by blocking the effects of CRF, a primary mediator of the body's stress response. In preclinical models, specifically adrenalectomized rats, a single dose of Astressin C demonstrated a prolonged duration of action, suppressing elevated adrenocorticotropic hormone (ACTH) levels for more than one week. The drug is currently in preclinical development for a variety of indications, including Irritable Bowel Syndrome (IBS), Postoperative Ileus (POI), and Congenital Adrenal Hyperplasia (CAH).
- Other names
- astressin-C
02
Targets
CRHR2 (Corticotropin-releasing hormone receptor 2)CRHR1 (Corticotropin-releasing factor receptor 1)CRHBP (Corticotropin-releasing factor-binding protein)
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