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atazanavir + cobicistat
- Development stage
- Approved
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Atazanavir + cobicistat** is an oral fixed-dose antiretroviral combination marketed as **Evotaz**. It contains atazanavir, an HIV-1 protease inhibitor that prevents proteolytic processing of viral Gag and Gag-Pol polyproteins and thereby blocks production of mature infectious virions, plus cobicistat, a CYP3A inhibitor used as a pharmacokinetic enhancer to raise and maintain atazanavir exposure. It is used with other antiretroviral medicines for treatment of HIV-1 infection in adults and eligible pediatric patients weighing at least 35 kg. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=83db29d7-5d85-49d6-8cb6-740473365cf8))
- Brand names
- Evotaz
- Other names
- ATV/catazanavir + cobicistatatazanavir/cobicistatcobicistat + atazanavircobicistat/atazanavir
02
Targets
ABCB1 (P-glycoprotein)SLCO1B3 (Organic anion transporting polypeptide 1B3)CYP3A4 (Cytochrome P450 3A4)ABCG2 (Breast cancer resistance protein)OATP1B1 (Organic anion transporting polypeptide 1B1)PR (Progesterone receptor)
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