atenolol + lisinopril (f10d03)

This entry refers to the comparative use of atenolol and lisinopril in a clinical trial conducted by the University of Pittsburgh titled Cognitive and Cerebrovascular Sequelae of Hypertension. Atenolol is a cardioselective beta-1 adrenergic receptor blocker, while lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. The study evaluated the differential effects of these two antihypertensive classes on cerebral blood flow and cognitive function in previously unmedicated hypertensive patients. Although the input suggests a combination, the trial specifically randomized patients to receive either medication as monotherapy to compare their vascular and neural outcomes. Both drugs are small molecules that do not significantly penetrate the blood-brain barrier, allowing the study to focus on vascular-mediated effects on brain function.

Brand names

TenorminPrinivilZestril

Other names

AtenololLisinopril