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atezolizumab + carboplatin + cyclophosphamide
- Development stage
- Preclinical
- Lead developer
- Genentech
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Atezolizumab + carboplatin + cyclophosphamide is a combination regimen consisting of three distinct drugs used in oncology. Atezolizumab is a monoclonal antibody that targets programmed death-ligand 1 (PD-L1), acting as an immune checkpoint inhibitor to enhance the anti-tumor immune response. Carboplatin and cyclophosphamide are both small molecule chemotherapeutic agents; carboplatin is a platinum-based compound that induces DNA crosslinking and apoptosis, while cyclophosphamide is an alkylating agent that interferes with DNA replication and cell division. This combination aims to leverage the immunomodulatory effects of atezolizumab with the cytotoxic actions of carboplatin and cyclophosphamide for synergistic anti-cancer activity.
- Brand names
- ParaplatinCytoxanTecentriq
- Other names
- carboplatin + cyclophosphamide + atezolizumabatezolizumab + carboplatin + cyclophosphamide combination
02
Targets
DNACD274 (Programmed cell death protein 1 ligand 1)
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