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atezolizumab + nivolumab + pembrolizumab

Development stage: Unknown
Lead developer: Genentech
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

This is a combination of three immune checkpoint inhibitors that work through similar but distinct mechanisms. Atezolizumab is a PD-L1 inhibitor, while nivolumab and pembrolizumab are PD-1 inhibitors. These drugs prevent the interaction between PD-1 and PD-L1, removing inhibition of immune responses seen in some cancers. They are primarily used in the treatment of various cancers including non-small cell lung cancer (NSCLC), melanoma, and other malignancies.

Targets

PDCD1 (Programmed cell death protein 1 receptor)CD274 (Programmed cell death protein 1 ligand 1)

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