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ATI-9242

Development stage: Phase 1
Lead developer: ARYx Therapeutics
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

ATI-9242 is a novel, atypical antipsychotic small molecule developed for the treatment of schizophrenia. It is a dibenzo(b,f)(1,4)oxazepine derivative designed to provide efficacy similar to clozapine but with fewer adverse effects. The drug acts on multiple neurotransmitter systems, including serotonin (5-HT1A agonist, 5-HT2A antagonist, 5-HT7 modulator), dopamine (D2 antagonist), acetylcholine (stimulant), GABA (modulator), and NMDA receptors (modulator). Its broad mechanism aims to address both positive and negative symptoms of schizophrenia while minimizing side effects commonly associated with other antipsychotics[1][3][4][5].

Other names: ATI 9242ATI9242ATI-9242

Targets

HTR7 (5-hydroxytryptamine receptor 7)HTR2A (Serotonin receptor 5-HT2A)DRD2 (Dopamine D2 Receptor)NMDAR (Glutamate receptor ionotropic, NMDA)AChR (Acetylcholine receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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