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ATM FOG refers to the use of atomoxetine for the treatment of freezing of gait (FOG) in Parkinson's disease. Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI) primarily approved for attention deficit hyperactivity disorder (ADHD), but it has been investigated off-label in clinical trials as a potential therapy to address gait disturbances, specifically freezing episodes, in patients with Parkinson's disease. The mechanism involves increasing synaptic concentrations of norepinephrine by inhibiting its reuptake, which may modulate motor and cognitive circuits implicated in Parkinsonian gait dysfunction[1].
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