Drug intelligence / Profile preview

ATM FOG

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

ATM FOG refers to the use of atomoxetine for the treatment of freezing of gait (FOG) in Parkinson's disease. Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI) primarily approved for attention deficit hyperactivity disorder (ADHD), but it has been investigated off-label in clinical trials as a potential therapy to address gait disturbances, specifically freezing episodes, in patients with Parkinson's disease. The mechanism involves increasing synaptic concentrations of norepinephrine by inhibiting its reuptake, which may modulate motor and cognitive circuits implicated in Parkinsonian gait dysfunction[1].

Brand names
ATM FOG
Other names
ATM FOG
02

Targets

NET (Norepinephrine Transporter)

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