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ATM siRNA

Development stage: Preclinical
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

ATM siRNA is a small interfering RNA designed to target and silence the expression of ataxia-telangiectasia mutated (ATM) kinase. ATM is a serine/threonine protein kinase that plays a central role in the DNA damage response (DDR) pathway, coordinating DNA double-strand break repair, cell cycle checkpoints, and apoptosis. Silencing ATM with siRNA is widely used in preclinical research to sensitize cancer cells to DNA-damaging agents (such as chemotherapy and radiation) and to study the role of the ATM pathway in cellular processes like oocyte development and aging.

Other names: ATM small interfering RNAsiATMsiRNA-ATM

Targets

ATM (Ataxia telangiectasia mutated protein)

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