Atomized Intraperitoneal Saline

Atomized Intraperitoneal Saline (AIS) is a sterile 0.9% sodium chloride solution administered as an atomized spray into the peritoneal cavity at the completion of surgery. Developed for use in clinical research by Loyola University, specifically in the Phase 4 SPRAY trial, AIS serves as a placebo control to evaluate the efficacy of atomized local anesthetics like ropivacaine for postoperative pain management in patients undergoing robotic-assisted pelvic surgery. The atomization technique is intended to provide uniform distribution of the saline across the peritoneal surfaces, allowing researchers to control for the physical effects of the delivery method and fluid volume when assessing the analgesic properties of the active drug.

Other names

Saline0.9% Sodium ChlorideAtomized saline