Drug intelligence / Profile preview

atorvast-natrapharm

Development stage
Unknown
Lead developer
Natrapharm
Modality
Small Molecules
Administration
Oral
01

Overview

Atorvast-Natrapharm is a generic oral film-coated tablet formulation of atorvastatin calcium, a synthetic lipid-lowering agent. It functions as a selective, competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme responsible for converting HMG-CoA to mevalonate during cholesterol biosynthesis in the liver. By reducing hepatic cholesterol levels, the drug triggers an increase in LDL-receptor expression on hepatocyte membranes, which enhances the uptake and clearance of circulating LDL-cholesterol. Marketed by the Filipino company Natrapharm, it is indicated for the management of various lipid disorders, including primary hypercholesterolemia, mixed dyslipidemia, hypertriglyceridemia, and dysbetalipoproteinemia. The medication is manufactured by Apotex in Canada and packaged locally by Lloyd Laboratories.

Brand names
Atorvast-Natrapharm
Other names
atorvastatin calcium
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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