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atorvastatin + quadrivalent seasonal influenza vaccine
- Development stage
- Unknown
- Lead developer
- Emory University
- Modality
- Vaccines & Immunotherapeutics, Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
A combination regimen consisting of the HMG-CoA reductase inhibitor atorvastatin and a quadrivalent seasonal influenza vaccine. This specific combination is being investigated by Emory University in a Phase 4 clinical trial to evaluate the "statin effect" on immune responses. Atorvastatin, a member of the statin family, is typically used to treat dyslipidemia by blocking the rate-limiting enzyme in cholesterol synthesis. The study aims to determine if statin therapy alters the magnitude or longevity of the antibody response to the influenza vaccine and assesses its impact on the gut microbiome.
- Other names
- atorvastatin calciumquadrivalent seasonal influenza vaccine
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)HA (Hemagglutinin)
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