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atorvastatin + raltegravir
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Atorvastatin + raltegravir refers to the concomitant administration of the HMG-CoA reductase inhibitor atorvastatin and the HIV integrase strand transfer inhibitor raltegravir. This combination was specifically evaluated in the AVIATOR study conducted by Radboud University Medical Center to assess pharmacokinetic drug-drug interactions in the context of treating hypercholesterolemia in patients with HIV infection. Atorvastatin is a standard-of-care statin used to lower LDL cholesterol and reduce cardiovascular risk, while raltegravir is an antiretroviral agent known for its favorable lipid profile. The Phase I study demonstrated that the two drugs do not have clinically significant pharmacokinetic interactions, allowing for their co-administration without dose adjustments.
- Brand names
- LipitorIsentress
- Other names
- AtorvastatinRaltegravir
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)Integrase allosteric pocket (HIV)
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