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atorvastatin + sodium bicarbonate
- Development stage
- Unknown
- Lead developer
- Taipei Medical University Shuang Ho Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Atorvastatin + sodium bicarbonate is an investigational combination therapy being evaluated by Taipei Medical University Shuang Ho Hospital for the treatment of autosomal dominant polycystic kidney disease (ADPKD). This therapeutic regimen combines atorvastatin, a standard HMG-CoA reductase inhibitor (statin), with sodium bicarbonate, an oral alkalizing agent. The rationale behind this combination is based on evidence that metabolic acidosis, which frequently occurs as chronic kidney disease (CKD) progresses, may limit the anti-inflammatory and Reno-protective effectiveness of statins while increasing their potential toxicity. By co-administering sodium bicarbonate to correct acidosis, the treatment aims to optimize the efficacy of atorvastatin in slowing kidney cyst growth and preserving renal function in adult ADPKD patients with Stage 1-3a CKD.
- Other names
- Atorvastatin and Alkali TherapyAtorvastatin plus Sodium Bicarbonate
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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