atovaquone + proguanil + artesunate + mefloquine

This entry represents a combination of four antimalarial drugs: atovaquone, proguanil, artesunate, and mefloquine. The provided information indicates that a specific product combining all four is not mentioned in the search results. Combinations discussed include atovaquone-proguanil (Malarone), and the addition of artesunate to atovaquone-proguanil has been studied for multidrug-resistant *Plasmodium falciparum* malaria with high cure rates. Mefloquine is typically used as a separate antimalarial or as follow-on treatment after initial therapy like IV artesunate. These medications are used in various combinations or sequentially based on clinical factors, resistance patterns, and region.