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ATR-COSF
- Development stage
- Preclinical
- Lead developer
- Azitra
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Topical
01
Overview
ATR-COSF is a preclinical-stage microbial therapy being developed by Azitra for cancer oncology support, specifically targeting skin-related adverse effects (such as skin flares or rashes) associated with cancer treatments. The drug is part of Azitra's proprietary Bio-SpE platform, which utilizes an engineered strain of *Staphylococcus epidermidis* to deliver therapeutic proteins directly to the skin microbiome. By leveraging the natural commensal properties of *S. epidermidis*, ATR-COSF aims to restore skin health and mitigate inflammation in patients undergoing systemic cancer therapies. The program is currently in the discovery and preclinical development stages.
02
Targets
KRT (Keratin, type I cuticular Ha7)
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