atRA-QM precursor

**atRA-QM precursor** is an experimental mutual prodrug that covalently links all-trans retinoic acid and a quinone methide precursor. The molecule was designed for incorporation into γ-poly(glutamic acid)-coated liposomes that target γ-glutamyl transferase-expressing tumors. Following esterase-triggered release, the all-trans retinoic acid component suppresses PIN1-associated oncogenic signaling, while the quinone methide precursor depletes intracellular glutathione and amplifies oxidative stress. In an MCF-7 breast-cancer xenograft model, the prodrug liposome formulation was reported to enhance antitumor activity without apparent systemic toxicity.

Other names

all-trans retinoic acid-quinone methide precursor mutual prodrugatRA-QM precursor