atriopeptin III

**Atriopeptin III** is a 24-amino acid peptide fragment (ANP 127-150) of rat atrial natriuretic peptide, functioning as a potent vasodilator, natriuretic, and diuretic agent[1][4][7]. Its primary mechanism is binding to natriuretic peptide receptors to induce vasodilation, promote sodium and water excretion, lower blood pressure, and increase glomerular filtration rate[1][3][5]. AP III demonstrates protective properties against ischemic acute renal failure and enhances cardiac relaxation by a mechanism involving endocardial endothelium[3][6][9]. Mostly characterized in animal models, it has been investigated for potential use in treating volume overload—including chronic renal failure, congestive heart failure, and possibly as a renal protective agent[1][3].

Other names

atrial natriuretic peptide (127-150)ANP (127-150)rat ANP (127-150)Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr