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Atriplex confertifolia pollen is a non-standardized allergenic extract derived from the pollen of the shadscale plant (*Atriplex confertifolia*). Manufactured by Allermed Laboratories, Inc., it is an FDA-approved biologic (BLA 102211) primarily utilized as a diagnostic skin test reagent to identify individuals with hypersensitivity to this specific weed pollen. The extract is administered via cutaneous, intradermal, or subcutaneous injection. Its pharmacologic mechanism involves triggering allergen-mediated immune responses, including the cross-linking of IgE on mast cells and basophils, which leads to the release of inflammatory mediators such as histamine. It may also be used in allergen immunotherapy to modulate IgG production and cell-mediated immunity, facilitating desensitization in allergic patients.
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