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Atriplex polycarpa pollen is an allergen extract derived from the pollen of the *Atriplex polycarpa* plant, commonly known as cattle-spinach or allscale, which belongs to the Chenopodiaceae family. This biological product is used for the diagnosis and treatment of IgE-mediated allergic diseases, such as allergic rhinitis and asthma, in individuals sensitized to this specific pollen. As a diagnostic tool, it is used in skin prick or intradermal testing to confirm sensitivity. As a therapeutic agent, it is used in allergen immunotherapy (AIT), where increasing doses of the extract are administered subcutaneously to induce immunological tolerance. The mechanism involves shifting the immune response away from a Th2-dominated allergic profile, reducing specific IgE levels, and increasing protective IgG4 antibodies and regulatory T-cell activity.
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