Drug intelligence / Profile preview

Atrosia

Development stage
Unknown
Lead developer
Weber & Weber
Modality
Small Molecules
Administration
Oral
01

Overview

Atrosia is a herbal medicinal product developed by Weber & Weber Biologische Arzneimittel, containing a concentrated dry extract of *Harpagophytum procumbens* (Devil's Claw) secondary roots. It is utilized for the supportive treatment of degenerative musculoskeletal conditions, including osteoarthritis and chronic joint pain. The therapeutic efficacy is largely attributed to iridoid glycosides, particularly harpagoside, which exhibit anti-inflammatory and analgesic properties by inhibiting the synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes through the modulation of cyclooxygenase and lipoxygenase pathways. It is registered in Germany as a pharmaceutical product for the relief of joint wear and tear.

Brand names
Atrosia
Other names
Harpagophytum procumbens root extractDevil's claw extractTeufelskralle-Extrakt
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ALOX5 (Arachidonate 5-lipoxygenase)TNFA (Tumor necrosis factor alpha (soluble))

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