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attenuated MVA monkeypox vaccine
- Development stage
- Phase 1
- Lead developer
- Shanghai Institute of Biological Products
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
The attenuated MVA monkeypox vaccine is a live-attenuated viral vaccine based on the Modified Vaccinia Ankara (MVA) strain, developed by the Shanghai Institute of Biological Products (SIBP), a subsidiary of Sinopharm (China National Biotec Group). MVA is a highly attenuated, non-replicating or poorly replicating orthopoxvirus that has been extensively used as a safe vaccine vector. This specific candidate is designed to prevent monkeypox (mpox) infection by inducing active immunity against the monkeypox virus. In clinical evaluation, it is administered via a two-dose subcutaneous schedule, with doses given 28 days apart. The vaccine is currently undergoing Phase I clinical trials in China to assess its safety and immunogenicity in adults.
- Other names
- MVA monkeypox attenuated live vaccineModified Vaccinia Ankara monkeypox vaccine减毒猴痘疫苗（MVA株）
02
Targets
OPXV MV/EEV antigens (Orthopoxvirus mature virion and extracellular enveloped virion surface antigens)
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