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attenuated Salmonella secreting IFN-β
- Development stage
- Preclinical
- Lead developer
- Chungnam National University
- Modality
- Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Gene Therapies, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Attenuated Salmonella secreting IFN-β is an engineered microbial therapy developed by researchers at Chungnam National University. The platform utilizes an attenuated *Salmonella Typhimurium* strain (BRD509 background with an rcsB gene deletion) designed to selectively colonize and proliferate within tumor tissues. It is engineered to secrete interferon-beta (IFN-β) through the flagellar type III secretion system (FT3SS), with secretion controlled by L-arabinose induction. This localized delivery of IFN-β modulates the tumor microenvironment, promotes N1-type neutrophil infiltration, and activates antitumor immune responses. Preclinical studies in colorectal cancer models have demonstrated that the therapy inhibits tumor growth and induces apoptosis, showing significant synergistic effects when combined with PD-L1 checkpoint blockade.
- Other names
- IFN-β secreting SalmonellaFT3SS-based IFN-β secreting SalmonellarcsB-deleted BRD509 Salmonella
02
Targets
IFNAR (Immune system modulation via type I interferon receptor)
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