Au-NH2

Au-NH2 is an amino-functionalized nanoparticle featuring an inert metallic gold core, developed as a potential therapeutic for acute myeloid leukemia (AML). It demonstrates selective cytotoxicity against AML cells while sparing healthy peripheral blood mononuclear cells (PBMCs) and macrophages. The drug's mechanism of action involves the induction of mitochondrial dysfunction through the inhibition of complexes I, III, and IV of the electron transport chain, leading to increased mitochondrial superoxide levels and loss of mitochondrial membrane potential. This triggers the intrinsic apoptotic pathway via BID cleavage, cytochrome c release, and caspase 3 activation. Additionally, Au-NH2 treatment results in lysosomal rupture and a rapid decrease in mTOR pathway activity, offering a potential nanotherapeutic approach for AML regardless of the patient's cytogenetic profile.

Other names

amino-functionalized gold nanoparticlesamino-functionalized nanoparticles with an inert metallic gold core