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AuNP-BBN-Pt2
- Development stage
- Preclinical
- Lead developer
- Universidade de Lisboa
- Modality
- Nanoparticles → Drug Delivery Systems, Peptides, Small Molecules
- Administration
- Intratumoral
01
Overview
**AuNP-BBN-Pt2** is a preclinical, gastrin-releasing peptide receptor-targeted gold-nanoparticle nanomedicine designed for prostate-cancer theranostics. It comprises a small gold nanoparticle functionalized with a DOTA derivative, the GRPR-targeting bombesin analog BBN[7-14], and a cisplatin-derived Pt(IV) prodrug connected through a PEGylated linker. The bombesin ligand promotes uptake by GRPR-positive tumor cells, while intracellular reduction of the Pt(IV) prodrug is intended to generate cytotoxic Pt(II) species that form DNA lesions. A related gallium-67-labeled derivative was investigated for SPECT-compatible imaging, but AuNP-BBN-Pt2 itself is the non-radiolabeled nanoparticle construct. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36593794/))
- Other names
- AuNP-BBN-Pt2AuNP-BBN-Pt-2AuNP-BBN-Pt 2gold nanoparticle + bombesin + Pt2
02
Targets
DNAGRPR (Gastrin-releasing peptide receptor)
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