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AuNP-BBN-Pt3
- Development stage
- Preclinical
- Lead developer
- Universidade de Lisboa
- Modality
- Nanoparticles → Drug Delivery Systems, Peptides, Small Molecules
- Administration
- Intraperitoneal
01
Overview
**AuNP-BBN-Pt3** is an experimental, GRPR-targeted gold-nanoparticle nanotherapeutic designed for prostate cancer theranostics. It comprises a small gold nanoparticle core functionalized with a thiolated DOTA derivative, the bombesin-derived GRPR-targeting peptide BBN[7-14], and a Pt(IV) platinum prodrug connected through a PEGylated linker. The BBN ligand is intended to promote uptake by gastrin-releasing peptide receptor-positive tumor cells, while the Pt(IV) payload is intended to generate DNA-damaging platinum activity after cellular activation. AuNP-BBN-Pt3 was evaluated in GRPR-positive PC3 prostate cancer cells as part of a preclinical nanoparticle series; it has not been reported as a clinical drug product. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC9760368/))
- Other names
- AuNP-BBN-Pt3AuNP-BBN-Pt-3AuNP-BBN-Pt 3
02
Targets
GRPR (Gastrin-releasing peptide receptor)DNA
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