aurantio-obtusin

Aurantio-obtusin is a naturally occurring anthraquinone compound primarily isolated from the seeds of Cassia obtusifolia and Cassia tora. It is characterized chemically as 1,3,7-trihydroxy-2,8-dimethoxy-6-methylanthracene‑9,10‑dione. Aurantio-obtusin exhibits a range of pharmacological activities including anti-inflammatory, antioxidant, antihypertensive (blood pressure-lowering), hypolipidemic (lipid-lowering), anticoagulant (notably as a potent thrombin inhibitor), vasorelaxation/vasodilatory effects and anti-allergic properties[1][4][5][6]. Mechanistically it inhibits thrombin activity by binding to its catalytic site and exosites; it also modulates inflammatory mediators such as TNF-alpha and interleukin‑4 while suppressing cyclooxygenase 2 expression and prostaglandin E2 production[4][5]. Additional reported actions include inhibition of platelet aggregation via multiple pathways (including PI3K/Akt/eNOS signaling) and activation of the aryl hydrocarbon receptor[6]. Clinically in China it is used for obesity management, diabetes and its complications (such as non-alcoholic fatty liver disease), allergic reactions and potentially for prevention/treatment of thrombotic diseases[5].

Other names

AurantioobtusinAurantio-obtusifolinCHEBI:37386