auristatin F

Auristatin F is a potent synthetic cytotoxic small molecule and a member of the auristatin family, derived from the natural product dolastatin 10. It acts as a microtubule inhibitor by binding to tubulin and inhibiting its polymerization, which leads to cell cycle arrest and apoptosis. Structurally, it is closely related to monomethyl auristatin F (MMAF) but features two methyl substituents on the N-terminal amino group. In addition to its antimitotic effects, auristatin F functions as a vascular damaging agent (VDA). Due to its extreme systemic toxicity, auristatin F is primarily utilized as a cytotoxic payload in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy, where it is linked to monoclonal antibodies to ensure selective delivery to malignant cells.

Other names

CAS 163768-50-1CAS163768-50-1CAS-163768-50-1