Aurodox

Aurodox is a linear polyketide antibiotic produced by *Streptomyces goldiniensis*, classified within the elfamycin group of antibiotics. It exhibits antibacterial activity primarily against Gram-positive bacteria, including *Streptococcus pyogenes*, and has been used experimentally for this purpose[2][3][7]. Aurodox acts by inhibiting protein synthesis through direct binding to elongation factor thermo-unstable (EF-Tu), preventing EF-Tu:GDP from dissociating from the ribosome and thereby blocking translation elongation[1][8]. In addition to its antibacterial effects, aurodox displays a unique anti-virulence mechanism in certain pathogenic Gram-negative bacteria such as enteropathogenic and enterohemorrhagic *Escherichia coli* (EPEC/EHEC). It inhibits the type III secretion system (T3SS) required for bacterial virulence by downregulating transcription of the master regulator Ler and also directly targets adenylosuccinate synthase (PurA), which is involved in T3SS regulation[1][4][5][6]. Unlike traditional antibiotics, aurodox does not induce Shiga toxin production. Its dual action makes it a promising candidate for antivirulence therapy.

Other names

Goldinomycin1-methylmocimycinGoldinodox