Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Aurograb
- Development stage
- Discontinued
- Lead developer
- Novartis
- Modality
- Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Aurograb is a human-derived single-chain variable fragment (scFv) antibody therapeutic developed for the treatment of severe, deep-seated Staphylococcal infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). Its mechanism of action involves targeting the *Staphylococcus aureus* ATP-binding cassette (ABC) transporter GrfA, an immunodominant antigen identified in septic patients. Aurograb was designed to act as an immunostimulant and was evaluated as an adjunct to standard vancomycin therapy, with preclinical studies showing synergistic effects in reducing *S. aureus* burden in animal models. However, clinical trials failed to demonstrate efficacy in humans[1][3][7]. Development was discontinued after disappointing results in Phase II/III trials[5].
- Brand names
- Aurograb
02
Targets
SpA (Staphylococcal protein A)GrfA (ATP-binding cassette transporter GrfA)
Beyond the preview
Go deeper on Aurograb.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Aurograb.