Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Aurora A inhibitor I
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Subcutaneous, Intraperitoneal, Parenteral, Implant, Topical, Rectal, Intranasal, Buccal, Vaginal
01
Overview
Aurora A inhibitor I (also known as TC-S 7010) is a potent, highly selective, ATP-competitive small molecule inhibitor of Aurora kinase A (AURKA) with an IC50 of 3.4 nM. Developed by Genentech, it exhibits approximately 1000-fold selectivity for Aurora kinase A over Aurora kinase B. The compound is widely used as a chemical biology tool to study mitotic spindle assembly, centrosome maturation, and cell cycle progression. In vitro, Aurora A inhibitor I induces G2/M cell cycle arrest and triggers apoptosis in various cancer cell lines, including colorectal carcinoma and leukemia cells.
- Other names
- Aurora A-IN-10Genentech Aurora A Inhibitor IGenentech Aurora Inhibitor IN-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
02
Targets
AURKC (Aurora kinase C)AURKB (Aurora kinase B)AURKA (Aurora kinase A)
Beyond the preview
Go deeper on Aurora A inhibitor I.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Aurora A inhibitor I.