Drug intelligence / Profile preview

aurotioprol

Development stage
Discontinued
Lead developer
Abbott
Modality
DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
Administration
Intramuscular
01

Overview

Aurotioprol is a gold salt classified as a disease-modifying antirheumatic drug (DMARD) and anti-inflammatory agent. It was primarily used for the treatment of rheumatoid arthritis and related rheumatic diseases. Aurotioprol is administered by intramuscular injection. Its mechanism of action, like other parenteral gold compounds, involves modulation of immune responses—affecting both humoral and cell-mediated immunity—and inhibition of inflammatory processes in polymorphonuclear cells and monocytes. The precise molecular target remains unclear but is believed to involve interference with lysosomal enzyme release, antibody-dependent cellular toxicity, and superoxide production[2][4][6][7].

Brand names
Allochrysine
Other names
sodium aurothiopropanol sulfonateaurotioprol acid

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