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Drug intelligence / Profile preview
Aurovit
- Development stage
- Unknown
- Lead developer
- Associazione Italiana per lo Studio del Pancreas
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Aurovit is a multivitamin supplement, specifically a B-complex formulation containing vitamins B1, B2, B6, B12, nicotinamide (PP), and calcium pantothenate. In the context of oncology, it has been utilized as a supportive care intervention in clinical trials, most notably the **AUROVIT study** (NCT02544451) sponsored by the **Associazione Italiana Per Lo Studio Del Pancreas (AISP)**. This Phase II trial evaluated the efficacy and safety of the combination of nab-paclitaxel and gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma. While Aurovit itself is not a primary antineoplastic agent, it is often administered to manage or prevent chemotherapy-induced peripheral neuropathy (CIPN), a common side effect of taxane-based therapies like nab-paclitaxel. The vitamins in the B-complex are essential for maintaining neuronal health and metabolic function, potentially mitigating the neurotoxic effects of cytotoxic drugs.
- Brand names
- Aurovit
- Other names
- Aurovit B-complexVitamin B-complex
02
Targets
GSR (Glutathione reductase)NF-κBTXNRD2 (Thioredoxin reductase 2)TPP (Thiamine pyrophosphate)
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