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Autigen siHES1#7
- Development stage
- Preclinical
- Lead developer
- Otologic Pharmaceutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratympanic
01
Overview
Autigen siHES1#7 is a small interfering RNA (siRNA) therapeutic candidate designed to selectively target and reduce Hes1 mRNA levels, thereby decreasing HES1 protein expression. HES1 is a transcription factor involved in the regulation of cell differentiation in various tissues, including the inner ear. By inhibiting HES1 expression, this drug aims to promote regeneration or repair of sensory hair cells in the cochlea, potentially offering a novel approach for treating hearing loss and related inner ear disorders. The drug is being developed for local delivery to the inner ear to maximize efficacy at the target site while minimizing systemic exposure[1][2].
- Brand names
- Autigen
- Other names
- siHes1siHes-1siHes 1Autigen siHES1#7
02
Targets
HES1 (Hairy and Enhancer of Split 1 Protein)
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