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AUTO8

Development stage: Phase 2
Lead developer: Autolus Therapeutics
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Parenteral

Overview

**AUTO8** is an investigational, autologous dual-targeting CAR-T cell therapy developed by Autolus Therapeutics in collaboration with University College London for plasma-cell disorders. The product is engineered to co-express a high-sensitivity B-cell maturation antigen CAR and a CD19 CAR, enabling recognition and CAR-mediated killing of BCMA-positive malignant plasma cells and potentially CD19-expressing disease-associated plasma-cell progenitors. AUTO8 is being evaluated in Phase 1 studies for relapsed or refractory multiple myeloma in the MCARTY trial and for systemic light-chain amyloidosis in the ALARIC trial. ([autolus.com](https://www.autolus.com/clinical-trials/))

Brand names: AUTO8AUTO-8AUTO 8
Other names: D8+CAT19+ CAR-T cellsD8 BCMA + CAT19 CAR-T cells

Targets

CD19 (B lymphocyte antigen CD19)BCMA (B-cell maturation antigen)

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