autogenous deciduous dental pulp mesenchymal stem cells + collagen + hydroxyapatite

This investigational cell therapy involves the use of autogenous mesenchymal stem cells derived from deciduous dental pulp (SHED) for the reconstruction of alveolar bone defects in pediatric patients with cleft lip and palate. Developed by Hospital Sírio-Libanês, the treatment utilizes a combination of these stem cells with a scaffold composed of collagen and hydroxyapatite. The mechanism of action relies on the osteogenic potential of the MSCs, which differentiate into osteoblasts and secrete growth factors to promote bone formation and integration within the cleft site, potentially offering a less invasive alternative to traditional autologous bone grafting (e.g., from the iliac crest).

Other names

SHEDStem cells from human exfoliated deciduous teethMSC-SHEDmesenchymal stem cells-Hospital Sirio-Libanes-cleft lip and palate