Drug intelligence / Profile preview

autologous adipose-derived mesenchymal stromal cells (Mayo Clinic, f11030)

Development stage
Unknown
Lead developer
Mayo Clinic
Modality
Stem Cell Therapies → Cell Therapies
Administration
Topical
01

Overview

An investigational autologous cell therapy developed by the Mayo Clinic to prevent biliary complications, such as strictures and leaks, in recipients of living donor liver transplantation (LDLT). The therapy involves harvesting mesenchymal stromal cells (MSCs) from the patient's own adipose tissue, followed by isolation and culture expansion. During the transplant procedure, the cells are applied directly to the biliary anastomosis site, typically via a cell-seeded mesh or suspension. The treatment utilizes the angiogenic, anti-fibrotic, and immunomodulatory properties of MSCs to enhance healing and reduce the incidence of post-operative biliary issues.

Other names
autologous adipose-derived mesenchymal stem cellsAdipose-derived autologous mesenchymal stromal cells

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