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Autologous adipose-derived stromal vascular fraction (La Paz)
- Development stage
- Unknown
- Lead developer
- FIBHULP
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intralesional
01
Overview
Autologous adipose-derived stromal vascular fraction (SVF) is an investigational cell therapy being developed by the Instituto de Investigación Hospital Universitario La Paz. It consists of a heterogeneous population of cells, including mesenchymal stem cells, endothelial progenitor cells, and immune cells, extracted from a patient's own adipose tissue via lipoaspiration. Unlike expanded adipose-derived stem cells (ASCs), SVF is processed and administered without cell culture expansion, typically through enzymatic digestion or mechanical dissociation. The therapy is administered via intralesional injection into the walls of rectovaginal fistulas, particularly in patients with Crohn's disease. The mechanism of action involves the local delivery of regenerative cells that promote angiogenesis, modulate the local immune response, and facilitate tissue repair to achieve fistula closure.
- Other names
- Adipose-derived stem cells without expandedStromal Vascular FractionAutologous SVFAdipose-derived stem cells-Instituto de Investigación Hospital Universitario La Paz-rectovaginal fistula
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