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autologous adipose stem cell mitochondria
- Development stage
- Unknown
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intracytoplasmic
01
Overview
**Autologous adipose stem cell mitochondria** refers to mitochondria isolated from mesenchymal stem cells derived from a patient's own adipose tissue, typically obtained via liposuction. These mitochondria are transplanted into oocytes during intracytoplasmic sperm injection (ICSI) to supplement mitochondrial function, aiming to improve oocyte quality, embryo development rates, euploidy, and pregnancy outcomes, particularly in patients with recurrent pregnancy loss, advanced maternal age, or poor oocyte quality. The approach leverages the high mitochondrial content, activity, and glycolytic metabolism of adipose-derived stem cells (ADSCs) to restore oocyte bioenergetics, reduce oxidative stress, and enhance cytoplasmic Ca²⁺ regulation without ethical concerns of allogeneic donation. Early research and pilot clinical studies indicate safety and potential efficacy in boosting transferable embryo rates, clinical pregnancy, and live birth rates[2][3][5].
- Other names
- adipose stem cell-derived mitochondria
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