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Autologous Anti-H3.3K27M TCR-expressing T-cells
- Development stage
- Phase 1
- Lead developer
- University of California, San Francisco
- Modality
- Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intravenous
01
Overview
Autologous Anti-H3.3K27M TCR-expressing T-cells are a form of T cell-based immunotherapy designed to target the H3.3K27M mutation found in diffuse midline gliomas (DMGs). This therapy involves collecting a patient's own T cells, genetically modifying them to express a T cell receptor (TCR) that specifically recognizes the H3.3K27M mutation, and then reinfusing these cells back into the patient to target and kill cancer cells expressing this mutation. The therapy is currently being investigated in clinical trials, particularly for pediatric and young adult patients with H3.3K27M-positive diffuse midline gliomas who are HLA-A*0201-positive. The treatment involves a conditioning regimen with fludarabine and cyclophosphamide followed by intravenous infusion of the modified T cells.
- Other names
- KIND T cells
02
Targets
H3.3K27M/HLA-A*02:01 (Histone H3.3-K27M neoantigen)
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