autologous bone marrow cell concentrate + platelet-rich plasma gel

A combination of **autologous bone marrow cell concentrate** (BMAC) and **platelet-rich plasma (PRP) gel** is a regenerative cell therapy used to promote tissue repair and healing by harnessing the synergistic effects of stem and progenitor cells from bone marrow and growth factors from activated platelets. - **Bone marrow cell concentrate** is obtained by aspirating bone marrow from the patient, processing it to concentrate stem and progenitor cells, and then re-injecting these cells at the site of injury. BMAC contains mesenchymal stem cells (MSCs), hematopoietic stem cells, and accessory cells that aid in tissue regeneration through differentiation, paracrine signaling, immunomodulation, and stimulation of local repair processes. - **Platelet-rich plasma gel** is prepared by centrifuging the patient’s blood to concentrate platelets, then activating them (often with calcium chloride or thrombin) to form a gel that releases a cocktail of growth factors (including PDGF, VEGF, TGF-β, IGF, and FGF) crucial for cell migration, proliferation, angiogenesis, and tissue regeneration[1][2][3][4][5][7]. - When combined, BMAC provides a source of reparative cells, while PRP gel delivers growth factors that stimulate these cells and accelerate healing. This therapy is primarily used in orthopedics and sports medicine to treat joint, tendon, ligament, bone, and cartilage injuries resistant to conventional therapies. - BMAC + PRP gel is **autologous** (sourced from the same patient), reducing risks of immune reaction and disease transmission. - The mechanism of action is multifactorial: direct engraftment and differentiation of mesenchymal stem/progenitor cells; paracrine release of immunomodulatory and regenerative signals; and amplification of wound healing cascades via PRP-derived growth factors.

Other names

autologous BMAC + PRP gelbone marrow aspirate concentrate + PRP gelautologous cell concentrate + PRP gel