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autologous bone marrow-derived mesenchymal stem cells (Ain Shams Maternity Hospital)
- Development stage
- Unknown
- Lead developer
- Ain Shams University Maternity Hospital
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Periurethral
01
Overview
This is an investigational autologous cell therapy consisting of bone marrow-derived mesenchymal stem cells (BM-MSCs) developed by the Ain Shams University Maternity Hospital for the treatment of female stress urinary incontinence (SUI) caused by intrinsic sphincter deficiency. The therapy involves harvesting a patient's own bone marrow, isolating and expanding the mesenchymal stem cells, and then re-injecting them periurethrally into the submucosal tissue of the proximal urethra. The mechanism of action relies on the regenerative potential of MSCs, which can undergo self-renewal and differentiate into muscle cells to repair and strengthen the damaged urethral sphincter muscle. A Phase 3 clinical trial (NCT02334878) has compared the efficacy of these stem cell injections against the standard surgical treatment, tension-free vaginal tape (TVT).
- Other names
- BM-MSCsautologous bone marrow-derived mesenchymal stem cellsStem Cells, Mesenchymal
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