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autologous bone marrow-derived mononuclear cells (PGIMER Chandigarh)
- Development stage
- Unknown
- Lead developer
- PGIMER Chandigarh
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intra-arterial, Intravenous
01
Overview
Autologous bone marrow-derived mononuclear cells (ABM-MNCs) is an experimental cell-based therapy developed by the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, for the treatment of type 2 diabetes mellitus. The procedure involves harvesting 200-300 ml of bone marrow from the patient, separating the mononuclear cell fraction using density gradient centrifugation, and re-infusing the cells, typically via the superior pancreaticoduodenal artery or peripheral intravenous infusion. The therapy aims to improve pancreatic β-cell function and insulin sensitivity, potentially reducing the requirement for exogenous insulin in patients with long-standing disease who have failed multiple oral antidiabetic drugs.
- Other names
- autologous bone marrow-derived stem cell transplantationABMSCT
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