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autologous bone marrow-derived mononuclear cells (University of Minnesota)

Development stage: Unknown
Lead developer: University of Minnesota Stem Cell Institute
Modality: Stem Cell Therapies → Cell Therapies
Administration: Intramyocardial

Overview

Autologous bone marrow-derived mononuclear cell therapy developed by the University of Minnesota for the treatment of end-stage heart failure. The therapy involves harvesting mononuclear cells from the patient's own bone marrow and delivering them via intramyocardial injection during left ventricular assist device (LVAD) implantation. The goal is to promote myocardial repair and regeneration, potentially improving heart function and reducing mortality in patients with advanced heart failure. The safety and efficacy were evaluated in the Phase 1/2 ASSURANCE trial (NCT00869024).

Other names: BMMNCsunfractionated autologous bone marrow mononuclear cellsASSURANCE stem cell therapy

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